Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A pathologist's approach to interstitial lung disease

R M Tuder1

  • 1Department of Pathology, University of Colorado Health Sciences Center, Denver 80262, USA.

Current Opinion in Pulmonary Medicine
|September 1, 1996
PubMed
Summary

This review details how lung cells contribute to interstitial lung diseases (ILD). Understanding these cellular interactions is key for diagnosing and managing ILD, a group of lung conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of Apoptosis in Amplifying Inflammatory Responses in Lung Diseases.

Journal of cell death·2017
Same author

Pulmonary Veno-occlusive Disease and Pulmonary Hypertension in Dogs: Striking Similarities to the Human Condition.

Veterinary pathology·2016
Same author

Trolox contributes to Nrf2-mediated protection of human and murine primary alveolar type II cells from injury by cigarette smoke.

Cell death & disease·2013
Same author

Role of Apoptosis in Amplifying Inflammatory Responses in Lung Diseases.

Journal of cell death·2011
Same author

Pulmonary vascular disease associated with parasitic infection--the role of schistosomiasis.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2010
Same author

HIV associated pulmonary emphysema: a review of the literature and inquiry into its mechanism.

Thorax·2008

Area of Science:

  • Pulmonology
  • Pathology
  • Cell Biology

Background:

  • Interstitial lung diseases (ILD) encompass a diverse pathological spectrum.
  • The lung interstitium is the primary target in these conditions.
  • Understanding cellular contributions is crucial for ILD management.

Purpose of the Study:

  • To review the role of cellular lung components in ILD pathogenesis.
  • To highlight clinically significant differential diagnoses within the ILD spectrum.
  • To discuss novel concepts linking ILD pathogenesis to morphologic presentation.

Main Methods:

  • Literature review of cellular and molecular mechanisms in ILD.
  • Analysis of pathogenetic pathways involving lung cells.
  • Correlation of pathobiology with clinical and morphological findings.

Related Experiment Videos

Main Results:

  • Specific cellular lung components, including macrophages, lymphocytes, mast cells, epithelial cells, and fibroblasts, are key players in ILD.
  • These cells mediate parenchymal destruction through the release of growth factors and cytokines.
  • Intercellular communication orchestrated by these cells drives ILD progression.

Conclusions:

  • Cellular interactions are central to the pathogenesis and progression of interstitial lung diseases.
  • A comprehensive understanding of these cellular roles aids in differential diagnosis and therapeutic strategies for ILD.
  • Further research into these cellular mechanisms may reveal new therapeutic targets for lung diseases affecting the interstitium.