Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Radionuclide imaging in interstitial lung disease

R P Baughman1, M Fernandez

  • 1Department of Internal Medicine, University of Cincinnati Medical Center, OH 45267-0564, USA.

Current Opinion in Pulmonary Medicine
|September 1, 1996
PubMed
Summary

Radionuclide imaging, including gallium uptake and 99mTc-DTPA aerosol scans, aids in evaluating interstitial lung disease (ILD) inflammation and predicting treatment response. However, limitations like cost and smoking interference exist for these diagnostic tools.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Management of anesthesia in a pregnant woman with severe aortic stenosis and von Willebrand's disease].

Revista espanola de anestesiologia y reanimacion·2005
Same author

Ropivacaine 0.1% with fentanyl 2 microg mL(-1) by epidural infusion for labour analgesia.

European journal of anaesthesiology·2005
Same author

Effect of telmisartan 80 mg once daily on 24-h blood pressure profile in patients with mild-to-moderate hypertension failing to respond to prior antihypertensive therapy.

International journal of clinical practice. Supplement·2004
Same author

Very low level laser therapy attenuates edema and pain in experimental models.

International journal of tissue reactions·2004
Same author

[Clinical guidelines for the prevention of colorectal cancer].

Gastroenterologia y hepatologia·2004
Same author

Population structure of Anisakis simplex (Nematoda) in harbor porpoises Phocoena phocoena off Denmark.

The Journal of parasitology·2004

Area of Science:

  • Nuclear medicine
  • Pulmonary medicine
  • Diagnostic imaging

Background:

  • Radionuclide imaging has a historical role in assessing interstitial lung disease (ILD).
  • Gallium uptake in the lungs correlated with inflammation in sarcoidosis and idiopathic pulmonary fibrosis.
  • Early methods showed potential for predicting disease progression and therapy response.

Purpose of the Study:

  • To review the utility and limitations of radionuclide techniques for ILD evaluation.
  • To discuss advancements and challenges in using gallium and 99mTc-DTPA scans for lung disease assessment.

Main Methods:

  • Review of recent publications on radionuclide imaging in ILD.
  • Analysis of gallium-67 uptake patterns in inflammatory lung conditions.
  • Evaluation of 99mTc-DTPA aerosol clearance as a biomarker for ILD.

Related Experiment Videos

Main Results:

  • Gallium uptake correlated with lung inflammation and predicted disease course but had limitations (cost, time, steroid interference).
  • Increased 99mTc-DTPA aerosol clearance is observed in ILD, including sarcoidosis.
  • Smoking significantly impacts 99mTc-DTPA clearance, limiting its use in smokers.

Conclusions:

  • Radionuclide imaging offers insights into ILD activity and prognosis.
  • Both gallium and 99mTc-DTPA scans present specific advantages and disadvantages for ILD diagnosis.
  • Further research and technique refinement are needed to overcome current limitations in radionuclide-based ILD assessment.