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Antioxidant enzymes and trace elements in hemodialyzed patients
C K Chen1, J M Liaw, J G Juang
1Department of Laboratory Medicine, Jen-Ai Hospital, Taichung, Taiwan, ROC.
Biological Trace Element Research
|July 1, 1997
Summary
Patients with chronic renal failure undergoing hemodialysis show decreased antioxidant enzyme activity and altered trace elements, indicating increased oxidative stress. Hemodialysis may worsen some effects despite improving certain parameters.
Area of Science:
- Biochemistry
- Nephrology
- Clinical Chemistry
Background:
- Chronic renal failure (CRF) is associated with oxidative stress.
- Hemodialysis is a common treatment for CRF, but its effects on oxidative stress markers are not fully understood.
Purpose of the Study:
- To investigate the levels of antioxidant enzymes and trace elements in hemodialysis patients.
- To assess the impact of hemodialysis on these markers and evaluate oxidative stress in CRF.
Main Methods:
- Measured plasma and erythrocyte levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSHPx).
- Analyzed trace elements in 26 hemodialysis patients and 25 healthy controls.
- Collected samples immediately before and after hemodialysis.
Main Results:
- Patients exhibited lower plasma SOD, CAT, GSHPx, and erythrocyte GSHPx before hemodialysis.
- Erythrocyte CAT and GSHPx remained lower post-hemodialysis compared to controls.
- Plasma GSHPx increased after hemodialysis, and correlations were found between SOD/copper and GSHPx levels.
Conclusions:
- Hemodialysis patients display significant alterations in antioxidant enzymes and trace elements, suggesting increased oxidative stress.
- While hemodialysis may improve some biochemical parameters, it can also exacerbate free radical damage and lipid peroxidation.