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Updated: Aug 9, 2026

Isolation of Sertoli Cells and Peritubular Cells from Rat Testes
Published on: February 8, 2016
Multinucleated stromal giant cells of testis
1Department of Histopathology, South Manchester University Hospitals NHS Trust, UK.
Multinucleated stromal giant cells are common in testicular tissue, appearing in 43% of autopsy cases. This finding is often age-related, with no clear hormonal or pathogenetic cause identified.
Area of Science:
- Reproductive biology
- Histopathology
Background:
- Multinucleated stromal giant cells (MSGCs) are occasionally observed in various tissues.
- Their presence and significance within the testicular interstitium are not well-documented.
Purpose of the Study:
- To determine the frequency of MSGCs in the testicular interstitium.
- To investigate potential etiological factors contributing to their occurrence.
Main Methods:
- Histological examination of testicular sections from 150 unselected autopsy cases.
- Analysis of cell morphology and distribution.
Main Results:
- MSGCs were identified in the testicular interstitium in 43% of the examined cases.
- No significant etiological association was found with hormonal or other pathogenetic influences.
Conclusions:
- The presence of MSGCs in the testicular interstitium is a relatively common finding.
- Age appears to be a significant factor in the occurrence of these cells.
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