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Molecular events in neutrophil transepithelial migration
1Department of Pathology, Emory University, Atlanta, GA 30322, USA.
Summary
Neutrophil transepithelial migration, crucial in inflammatory diseases, involves specific molecular interactions. CD47 plays a key role after CD11b/CD18-mediated adhesion to epithelial cells.
Area of Science:
- Immunology
- Cell Biology
- Gastroenterology
Background:
- Neutrophil transepithelial migration is integral to inflammatory diseases across multiple organ systems.
- Epithelial cells dynamically modulate this migration process, impacting barrier function and secretion.
Purpose of the Study:
- To review the molecular mechanisms governing neutrophil migration across epithelial barriers.
- To highlight the roles of specific cell adhesion molecules in this process.
Main Methods:
- In vitro modeling using polarized intestinal epithelial monolayers.
- Characterization of molecular interactions between neutrophils and epithelial cells.
Main Results:
- Neutrophil migration is dependent on the beta 2 integrin CD11b/CD18.
- CD47 is implicated as a crucial component, with CD47-dependent events occurring post-CD11b/CD18 adhesion.
Conclusions:
- Understanding these molecular interactions is key to addressing inflammatory diseases.
- CD47 emerges as a significant factor in neutrophil transepithelial migration.