Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tyrosine phosphorylation and cadherin/catenin function

J M Daniel1, A B Reynolds

  • 1Dept of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-2175, USA.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|November 18, 1997
PubMed
Summary

Protein tyrosine kinase (PTK) transformation disrupts cell adhesion by phosphorylating Arm catenins, key partners of cadherins. This phosphorylation likely alters cadherin function and cell-cell adhesion dynamics.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Estradiol is not protective against angiotensin II-induced hypertension in middle-aged ovariectomized rats.

Physiological reports·2025
Same author

Interactions of Electromagnetic Radiation and Subatomic Particles with Matter - Part 2.

Clinical oncology (Royal College of Radiologists (Great Britain))·2021
Same author

Interactions of Electromagnetic Radiation and Subatomic Particles with Matter - Part 1.

Clinical oncology (Royal College of Radiologists (Great Britain))·2021
Same author

Estrogen receptor α: a critical role in successful female cognitive aging.

Climacteric : the journal of the International Menopause Society·2021
Same author

Previous Midlife Oestradiol Treatment Results in Long-Term Maintenance of Hippocampal Oestrogen Receptor α Levels in Ovariectomised Rats: Mechanisms and Implications for Memory.

Journal of neuroendocrinology·2016
Same author

Kaiso depletion attenuates transforming growth factor-β signaling and metastatic activity of triple-negative breast cancer cells.

Oncogenesis·2016

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Cadherin-mediated cell-cell adhesion is crucial for tissue integrity.
  • Protein tyrosine kinase (PTK) transformation disrupts normal cell adhesion.
  • Cadherins are cell adhesion molecules, but their direct phosphorylation by PTKs is limited.

Purpose of the Study:

  • To review the literature on the role of Arm catenins in PTK-induced changes in cadherin function.
  • To explore the mechanisms by which tyrosine phosphorylation of Arm catenins affects cell adhesion.
  • To propose models for how Arm catenin phosphorylation regulates or perturbs cadherin complexes.

Main Methods:

  • Literature review of existing studies on cadherins, Arm catenins, and PTKs.
  • Analysis of data linking tyrosine phosphorylation to cadherin complex behavior.

Related Experiment Videos

  • Discussion of proposed models for phosphorylation-mediated regulation.

    • Main Results:

    • Arm catenins (p120ctn, beta-catenin, plakoglobin) are excellent PTK substrates.
    • These catenins bind to the cytoplasmic region of cadherins, modulating adhesion and cytoskeletal linkage.
    • Tyrosine phosphorylation of Arm catenins is implicated in altered cadherin function, though mechanisms are unclear.

    Conclusions:

    • Arm catenins, not cadherins, are the primary mediators of PTK-induced alterations in cell adhesion.
    • Tyrosine phosphorylation of Arm catenins is a key regulatory event in cadherin complex function.
    • Further research is needed to elucidate the precise mechanisms of action for these phosphorylation events.