Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pain and its treatments

P Cesaro1, H Ollat

  • 1Departement de Neurosciences et INSERM U421, CHU Henri Mondor, Créteil, France.

European Neurology
|January 1, 1997
PubMed
Summary

This review covers pain definition, pathophysiology, clinical trial methods, and treatments, including drugs and surgery. It highlights advancements in understanding pain mechanisms and therapeutic strategies for better patient care.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A comprehensive RCT in screening, surveillance, and diagnostic AI-assisted colonoscopies (ACCENDO-Colo study).

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2025
Same author

AMF communities associated to Vitis vinifera in an Italian vineyard subjected to integrated pest management at two different phenological stages.

Scientific reports·2020
Same author

Metaproteomic characterization of theVitis vinifera rhizosphere.

FEMS microbiology ecology·2018
Same author

Barriers against split-dose bowel preparation for colonoscopy.

Gut·2016
Same author

[Drug treatment of early-stage (de novo and "honeymoon") Parkinson disease].

Revue neurologique·2014
Same author

Low level of ventricular CSF orexin-A is not associated with objective sleepiness in PD.

Sleep medicine·2011

Area of Science:

  • Pain research and treatment methodologies.

Background:

  • Defining pain as a subjective experience associated with tissue damage, noting challenges in assessing pain in non-verbal individuals.
  • Key physiopathological discoveries include substance P release, nociceptive pathway analysis, and endomorphin characterization.
  • Distinguishing between 'windup' and central sensitization and utilizing neuropathic pain models to understand pathophysiology.

Purpose of the Study:

  • To provide a comprehensive overview of pain and its management.
  • To discuss the definition, physiopathology, and clinical trial methodologies in pain research.
  • To review current and future therapeutic strategies, including pharmacological and surgical interventions.

Main Methods:

  • Review of existing literature on pain definition, pathophysiology, and treatment.
  • Analysis of advancements in clinical trial methodologies for pain research.
  • Examination of pharmacological and surgical approaches for pain management.

Main Results:

  • Pain assessment requires nonverbal behavioral information for individuals unable to self-report.
  • Significant progress in understanding pain pathways, central sensitization, and neuropathic pain models.
  • Substantial increase in the number and quality of randomized clinical trials since 1950.

Conclusions:

  • Pain research has evolved significantly, with major advancements in understanding its complex mechanisms.
  • Current treatments involve a range of analgesics, opioids, antidepressants, and surgical options.
  • Future directions focus on refining therapeutic strategies and improving pain management outcomes.

Related Experiment Videos