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Observations on plasma creatine phosphokinase activity in dogs
The Veterinary Record
|April 24, 1976
Summary
Plasma creatine phosphokinase (PCPK) levels in dogs are not affected by mealtime or body mass. Moderate physical activity showed a significant correlation with PCPK levels, which were 10 times higher than previously reported.
Area of Science:
- Veterinary Medicine
- Biochemistry
- Enzymology
Background:
- Plasma creatine phosphokinase (PCPK) is an enzyme crucial for energy metabolism in muscle tissue.
- Understanding normal PCPK levels in dogs is essential for diagnosing muscle-related disorders.
Purpose of the Study:
- To establish reference ranges for PCPK activity in clinically normal adult dogs.
- To investigate the influence of physical activity, body mass, and feeding on PCPK levels.
Main Methods:
- PCPK activity was measured in 14 healthy adult dogs of various breeds using an activated enzyme assay at 30°C.
- Factors such as sampling time, body mass, feeding status, and physical activity were considered.
Main Results:
- Mean PCPK activity was 22.9 IU/L.
- No significant influence of sampling time, body mass, or feeding on PCPK levels was observed.
- A significant positive correlation was found between PCPK levels and moderate physical activity (P < 0.05).
Conclusions:
- The activated enzyme assay yields PCPK levels approximately 10 times higher than non-activated methods.
- Moderate physical activity is a key factor influencing PCPK levels in healthy dogs.
- These findings provide a basis for interpreting PCPK activity in canine diagnostics.