Related Experiment Video
Updated: Sep 25, 2026

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens
Published on: February 15, 2011
Does clofazimine have a prophylactic role against neuritis?
1Schieffelin Leprosy Research and Training Centre (SLR&TC), Tamil Nadu, India.
Abstract:
A study was undertaken with the aim of testing the usefulness of clofazimine as a prophylactic agent against neuritis and nerve damage. A modified regimen, using initial high doses of clofazimine followed by regular multibacillary multidrug therapy (MB-MDT) WHO regimen, was given to a series of consecutive cases of high risk borderline leprosy patients, fulfilling defined selection criteria (n = 65). These patients were studied for the incidence of neuritis/Type I reaction, over a period of 2 years. Results were compared with a matched series of consecutive cases treated only with regular MB-MDT WHO regimen (n1 = 57). The difference in incidence rates of neuritis between the two groups was significant (p < 0.01), suggesting that clofazimine may have a useful prophylactic role against neuritis/Type I reaction and nerve damage.
More Related Videos
Related Concept Videos
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Cryptococcal Meningitis
Inhibitors of Viral Protein Synthesis
Antifungal Agents

