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Extended-interval dosing of aminoglycosides
1Mount Sinai School of Medicine, Department of Medicine, New York, NY 10029-6574, USA.
The Mount Sinai Journal of Medicine, New York
|November 19, 1997
Summary
Extended-interval dosing of aminoglycosides maintains efficacy while reducing toxicity. This approach offers a safe and cost-effective strategy against bacterial resistance, enhancing antibiotic therapy.
Area of Science:
- Pharmacology
- Infectious Diseases
- Clinical Pharmacy
Background:
- Aminoglycoside use has decreased due to newer agents perceived as less toxic.
- Traditional dosing regimens may not optimize aminoglycoside efficacy and safety.
- Antibiotic resistance necessitates re-evaluation of established antimicrobial strategies.
Purpose of the Study:
- To evaluate the efficacy and safety of extended-interval dosing for aminoglycosides.
- To compare extended-interval dosing with traditional every-8-hour dosing.
- To assess the role of aminoglycosides in combating bacterial resistance.
Main Methods:
- Comprehensive literature search on aminoglycoside extended-interval dosing.
- Analysis of bacterial resistance patterns from The Mount Sinai Hospital.
- Development of a nomogram for extended-interval aminoglycoside administration.
Main Results:
- Extended-interval aminoglycoside dosing is as effective as traditional every-8-hour dosing.
- This dosing strategy may lead to reduced aminoglycoside-associated toxicities.
- Aminoglycosides demonstrate greater susceptibility to bacterial resistance compared to newer antibiotics.
Conclusions:
- Extended-interval aminoglycoside dosing provides safe and effective therapy.
- This regimen offers potential cost savings and ease of administration.
- Increased use of aminoglycosides can be beneficial for specific bacterial infections, particularly in the context of resistance.