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Differentiation commitment in normal hemopoiesis and leukemic transformation
D Metcalf1, N A Nicola, L Robb
1Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.
Journal of Cellular Physiology
|November 20, 1997
Abstract:
Differentiation commitment events are essential for the initiation of hemopoiesis and, in one form or another, occur continuously during adult hemopoiesis. The most studied type of differentiation commitment decision a hemopoietic cell can make involves the alternative choice of self-renewal versus the formation of progeny destined for maturation. Aberration in this commitment choice is a key abnormality necessary for the formation of a leukemic population.