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Antibodies of oncornaviruses and virus-associated antigens in cancer patients

M S Berdinskikh, V S Krosteleva, P N Kosiakov

    Voprosy Virusologii
    |March 1, 1976
    PubMed

    Insights

    Specific antibodies to oncornaviruses type D were detected in patients with gynecological cancers and benign genital tumors. These antibodies were also found in healthy donors with blood group O, suggesting a potential link to oncornaviruses.

    Area of Science:

    • Virology
    • Immunology
    • Oncology

    Context:

    • Oncornaviruses, a type of retrovirus, have been implicated in various cancers.
    • Identifying virus-associated antigens is crucial for understanding disease pathogenesis.
    • Gynecological cancers and benign genital tumors represent significant health concerns.

    Purpose:

    • To investigate the presence of specific antibodies against oncornaviruses type D and their associated antigens.
    • To compare antibody prevalence in patients with gynecological cancer, benign genital tumors, and healthy individuals.

    Summary:

    • Antibodies to oncornaviruses type D and induced virus-associated antigens were detected using complement fixation tests (CFT) and adsorption methods.
    • Prevalence was 72.4% in sera from patients with gynecological cancer and sarcoma, and 62.5% in patients with benign genital tumors.
    • Notably, 73% of healthy donors with blood group O also exhibited similar antibodies.

    Impact:

    • This research may contribute to understanding the role of oncornaviruses in gynecological malignancies and benign tumors.
    • Findings could inform the development of diagnostic markers or therapeutic strategies targeting oncornaviruses.
    • The presence of antibodies in healthy individuals warrants further investigation into potential co-infection or cross-reactivity.

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