Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prospects for intravascular gene therapy

R C Smith1, K Walsh

  • 1Division of Cardiovascular Research, St. Elizabeth's Medical Center, Boston, Massachusetts 02135, USA.

Journal of Clinical Apheresis
|January 1, 1997
PubMed
Summary

This review covers gene delivery systems and genes for vascular gene therapy. It explores strategies for neovascularization and preventing restenosis via cell proliferation inhibition and re-endothelialization.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulmonary Vein Isolation: Patient Experience under Conscious Sedation versus Anaesthesia.

Irish medical journal·2026
Same author

Where do we go from here? The personal impact of adverse events and complications in surgeons: Results from a cross-sectional study.

The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·2025
Same author

Cardiovascular risk assessment for osteoporosis patients considering Romosozumab.

Bone·2024
Same author

Uncertainty in low back pain care - insights from an ethnographic study.

Disability and rehabilitation·2022
Same author

Comparing traditional modeling approaches versus predictive analytics methods for predicting multiple sclerosis relapse.

Multiple sclerosis and related disorders·2022
Same author

The toxic cutaneous effects of Gamma Butyrolactone (GBL).

Burns : journal of the International Society for Burn Injuries·2021

Area of Science:

  • Biomedical Engineering
  • Molecular Biology
  • Cardiovascular Research

Background:

  • Vascular diseases pose significant health challenges.
  • Current treatments for vascular conditions have limitations.
  • Gene therapy offers a promising therapeutic avenue.

Purpose of the Study:

  • To review gene delivery systems for vascular gene therapy.
  • To identify candidate genes for vascular gene therapy strategies.
  • To discuss therapeutic approaches for neovascularization and restenosis.

Main Methods:

  • Literature review of gene delivery systems.
  • Analysis of in vivo studies on gene therapy for vascular diseases.
  • Evaluation of strategies targeting smooth muscle cell proliferation and re-endothelialization.

Main Results:

  • Various gene delivery systems are under investigation.
  • Several candidate genes show potential for vascular gene therapy.
  • In vivo models demonstrate efficacy in promoting neovascularization and limiting restenosis.

Conclusions:

  • Gene therapy holds significant promise for treating vascular diseases.
  • Further research into gene delivery and candidate genes is warranted.
  • Targeting smooth muscle cell proliferation and re-endothelialization are key strategies.

Related Experiment Videos