[Nonspecific cell-mediated immunity in chronic hepatitis studied in vitro]

A considerable damage of immunogenesis with involving both humoral and cellular immunity was recently established in certain forms of chronic hepatitis. The investigation of nonspecific cellular immunity of following-up the transformation activity of lymphocytes in vitro in stimulation with PHA provides data for the inhibition of that immunity in chronic agressive hepatitis with manifestations of hypersplenia. In the progress of the disease, the increase or decrease of the transformation activity of lymphocytes correspond to the improvement or deterioration of the disease. After splenectomy transformation activity of lymphocytes is increased parallelly with the favourable effect as regards the basic ailment and the hematological indices.