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[Histaminergic neuron system and neural plasticity]

T Watanabe1

  • 1Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan.

Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology
|August 1, 1997
PubMed
Summary

The brain's histaminergic neuron system, originating in the tuberomammillary nucleus, helps maintain homeostasis. Histamine appears to protect against various stimuli, including drug effects and brain injury.

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Area of Science:

  • Neuroscience
  • Neurochemistry

Context:

  • The histaminergic neuron system, primarily located in the tuberomammillary nucleus (TM) of the posterior hypothalamus, projects widely throughout the brain.
  • This system's extensive reach suggests a role in regulating global brain activity.

Purpose:

  • To investigate the role of the histaminergic system in response to various invasive stimuli.
  • To examine the effects of pharmacological manipulations on methamphetamine-induced behavioral sensitization, ischemia-induced neuronal cell death, and electroconvulsive shock.

Summary:

  • Pharmacological manipulation of the histaminergic neuron system was studied in models of methamphetamine sensitization, brain ischemia, and electroconvulsive shock.
  • Nerve degeneration led to increased postsynaptic H3 receptors.
  • Findings suggest histamine plays a protective role in maintaining homeostasis against diverse physiological challenges.

Impact:

  • Provides evidence for histamine's homeostatic function in the central nervous system.
  • Highlights the histaminergic system's involvement in neuroprotection and resilience.
  • Suggests potential therapeutic targets within the histaminergic system for neurological insults.

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