SCFA transport in the forestomach of ruminants

Short-chain fatty acids are the main end-products of microbial metabolism in the forestomach of ruminants. SCFA produced by the microorganisms are rapidly absorbed across forestomach epithelia and can cover up to 80% of the energy requirement of the animal. Although there is a great concentration gradient for SCFA between the forestomach content and the blood favoring passive transport, (secondary) active transport mechanisms are likely involved in SCFA permeation across the epithelia. (Secondary) active SCFA transport seems to be mediated by an anionic exchange system. The system interacts with other anions like chloride and bicarbonate. Similar to the large intestine of various species, SCFA can stimulate sodium transport probably by activating a Na+/H+ exchange located in the apical membrane. However, in contrast to the large intestine, SCFA transport itself seems to be independent from sodium. Part of the absorbed SCFA does not reach the blood side in the original form because it is metabolized in the epithelial cell. Metabolism, in turn, influences SCFA transport.