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[Acute eosinophilic pneumonia associated with aspirin]
K Uchida1, S Sekiguchi, K Matsuda
1Department of Respirology, Inada-Nobovito Hospital.
Nihon Kyobu Shikkan Gakkai Zasshi
|August 1, 1997
Summary
A young man developed acute eosinophilic pneumonia after starting smoking and taking aspirin. His symptoms resolved spontaneously, linked to aspirin use, a previously unreported association.
Area of Science:
- Pulmonology
- Toxicology
Background:
- Acute eosinophilic pneumonia (AEP) is a rare condition characterized by rapid onset of respiratory symptoms.
- Smoking and certain medications are potential triggers for AEP.
Observation:
- A 21-year-old male presented with acute dyspnea and fever, diffuse infiltrates, and pleural effusions on chest radiograph.
- No infectious cause was identified; symptoms resolved spontaneously.
- Elevated interleukin-5 levels in blood and bronchoalveolar lavage fluid normalized within a week.
Findings:
- A diagnosis of acute eosinophilic pneumonia was made.
- A lymphocyte stimulation test strongly associated symptom onset with aspirin ingestion.
- This represents the first reported case of aspirin-induced acute eosinophilic pneumonia.
Implications:
- Aspirin should be considered as a potential cause of acute eosinophilic pneumonia.
- This case expands the known iatrogenic causes of AEP.
- Further research may elucidate the mechanisms of aspirin-induced AEP.