Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Bi-dimensional scaling map (BDS-Map): an approach for building large genetic maps

S Goldberg¹, P Ferrand, N Q Nguyen

¹Centre de Bioinformatique, INSERM U 155, Paris, France.

Computer Applications in the Biosciences : CABIOS

|November 21, 1997

Summary

This study introduces Bi-Dimensional Scaling Map (BDS-Map), a novel approach for genetic map construction. BDS-Map globally optimizes marker order and distances, overcoming limitations of traditional methods.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Histopathological Examination of Pancreatectomy Specimens From Patients With Locally Advanced Pancreatic Adenocarcinoma Following Endoscopic Ultrasound-Guided Phosphorus-32 (<sup>32</sup>P) Implantation and Chemotherapy.

Pathology international·2026

Same author

Endoscopic Ultrasound Guided Portal Pressure Gradient Measurement in Predicting Outcomes of Abdominal Surgery in Patients With Chronic Liver Disease.

Journal of gastroenterology and hepatology·2025

Same author

Biochemical, gas exchange, and chlorophyll fluorescence analysis of maize genotypes under drought stress reveals important insights into their interaction and homeostasis.

Photosynthetica·2024

Same author

InterCarb: A Community Effort to Improve Interlaboratory Standardization of the Carbonate Clumped Isotope Thermometer Using Carbonate Standards.

Geochemistry, geophysics, geosystems : G(3)·2021

Same author

Faecal microbiota transplantation for Clostridium difficile infection resulting in a decrease in psoriatic arthritis disease activity.

Clinical and experimental rheumatology·2019

Same author

A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers.

Nature communications·2018

Area of Science:

Genetics
Bioinformatics
Computational Biology

Background:

Traditional genetic mapping divides markers into linkage groups, providing local orders.
Existing methods face limitations in handling large marker sets and global order inference.

Purpose of the Study:

To define a new strategy for genetic map construction that considers the entire marker set globally.
To introduce and validate the Bi-Dimensional Scaling Map (BDS-Map) approach.

Main Methods:

The BDS-Map approach projects markers into an additional orthogonal dimension.
It utilizes dynamical forces derived from two-point analysis to optimize marker spatial locations.
The method is tested on real genetic data and simulated datasets.

Related Experiment Videos

Main Results:

BDS-Map infers marker orders and distances within genetic maps.
The approach was successfully applied to real data with 16 and 70 markers.
Efficiency was demonstrated on simulated data comprising 50 maps with 70 markers each.

Conclusions:

BDS-Map offers a global strategy for genetic map construction.
This method addresses limitations of traditional, localized approaches.
The approach provides an efficient way to infer marker order and distances.