Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell cycle regulation by the ubiquitin pathway

M Pagano1

  • 1Department of Pathology and Kaplan Cancer Center, New York University Medical Center, New York 10016, USA.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|November 21, 1997
PubMed
Summary

Two ubiquitin-dependent pathways regulate the cell division cycle. One pathway uses the Cdc34 E2 enzyme to degrade phosphorylated substrates for S phase entry, while another targets destruction boxes for cell cycle progression.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seawater mercury species and phytoplankton biomass drive bioaccumulation in a coastal plankton food web.

Chemosphere·2026
Same author

Locally advanced NSCLC: overview of real-world pattern of recurrence in durvalumab era (LEOPARD trial).

Lung cancer (Amsterdam, Netherlands)·2025
Same author

Receiver design for the REACH global 21-cm signal experiment.

Experimental astronomy·2025
Same author

Water column distribution of zooplanktonic size classes derived from in-situ plankton profilers: Potential use to contextualize contaminant loads in plankton.

Marine pollution bulletin·2023
Same author

Clinical profile and outcome of cardiomyopathies in infants and children seen at a tertiary centre.

International journal of cardiology·2022
Same author

Toxicological Evaluation of Acetylsalicylic Acid in Non-Target Organisms: Chronic Exposure on <i>Mytilus galloprovincialis</i> (Lamarck, 1819).

Frontiers in physiology·2022

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Ubiquitin-dependent proteolysis is crucial for cell cycle regulation.
  • Two key pathways have emerged in regulating cell division.

Purpose of the Study:

  • To review the established ubiquitin-dependent proteolytic pathways involved in cell cycle control.
  • To highlight the mechanisms and substrates targeted by these pathways.

Main Methods:

  • Review of recent studies on ubiquitin-mediated protein degradation.
  • Analysis of the roles of E2 enzymes and E3 complexes in cell cycle regulation.

Main Results:

  • The Cdc34 E2 enzyme pathway degrades phosphorylated substrates, like p40Sic1, enabling S phase entry in S. cerevisiae.

Related Experiment Videos

  • A second pathway, involving the anaphase-promoting complex/cyclosome, degrades anaphase inhibitors and mitotic cyclins via destruction box motifs to regulate chromosome segregation and mitotic exit.

    • Conclusions:

    • Ubiquitin-dependent proteolysis plays a vital role in precise cell cycle progression.
    • Distinct ubiquitinylation pathways target specific substrates to control critical cell division events.