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Staphylococcus aureus and Candida albicans infection (animal experiments)
Zentralblatt Fur Bakteriologie, Parasitenkunde, Infektionskrankheiten Und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie Und Parasitologie
|May 1, 1976
Summary
Candida albicans and Staphylococcus aureus can co-infect mice, with fungal byproducts supporting bacterial growth. This highlights the need to control mouse microflora in mycological research.
Area of Science:
- Mycology
- Bacteriology
- Infectious Diseases
Background:
- Candida albicans is a fungus known for its proteolytic activity.
- Staphylococcus aureus is a common bacterium that can be part of the normal microflora.
- Endogenous infections arise from pathogens already present in the host.
Purpose of the Study:
- To investigate the simultaneous isolation of Candida albicans and Staphylococcus aureus from mouse infections.
- To understand the relationship between these two pathogens during infection.
- To assess the clinical significance of their co-existence.
Main Methods:
- Mice were inoculated intraperitoneally with Candida albicans.
- Pathogens were isolated from peritoneal abscesses.
- Histopathological examination was used to study pathogen proximity.
Main Results:
- Candida albicans and Staphylococcus aureus were simultaneously isolated from peritoneal abscesses.
- Histopathology showed Staphylococcus aureus near Candida cells within granulomata.
- Proteolytic byproducts of Candida albicans likely support Staphylococcus aureus growth.
Conclusions:
- The co-existence of Candida albicans and Staphylococcus aureus in endogenous infections is clinically relevant.
- Proteolytic activity of Candida albicans facilitates Staphylococcus aureus proliferation.
- Controlling bacterial flora in mice is crucial for accurate mycological studies.