[The dynamics of morphologic changes in the sensomotor cortex of rats with acute hypoxia and its sequelae]

The authors studied by light optical methods the dynamics of morphological symptom of functional and organic changes of neurons in the sensomotor cortex, in paraphine and semithin layers of the cortex of postmortem cases in white rats who had suffered from acute hypoxial hypoxia with a subsequent survival from 0--4 hours. These data were correlated with electronomicroscopic studies as well as with biochemical data presented in current literature. On the basis of such information the mechanism of cellular polymorphism changes as well as the pathogenesis of irreversible shifts in the brain cortex during hypoxia or discusse. The results of such studies may serve to a certain degree as a morphological basis for a clarification of pathomorphological changes in early and late neurological symptoms in the post reanimation periods in humans. Evidently, such data may promote an eleboration of therapuetical and prophylactical measures, preventing the development of irreversible changes in the brain due to hypoxia.