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Structure, recognition and adaptive binding in RNA aptamer complexes

D J Patel1, A K Suri, F Jiang

  • 1Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

Journal of Molecular Biology
|November 22, 1997
PubMed
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This review details RNA aptamer structures, revealing principles of RNA architecture and molecular recognition for high-affinity binding of molecules like adenosine monophosphate and tobramycin.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Structural Biology

Background:

  • RNA aptamers exhibit remarkable specificity and affinity for diverse targets.
  • Understanding RNA structure is key to elucidating molecular recognition mechanisms.

Purpose of the Study:

  • To review solution structures of RNA aptamer complexes.
  • To analyze structural principles governing RNA-aptamer interactions.
  • To highlight diversity in RNA architecture and binding.

Main Methods:

  • Solution structural characterization of RNA aptamer complexes.
  • Hydrogen exchange measurements for base-pair kinetics.
  • Comparative structural analysis.

Main Results:

Related Experiment Videos

  • Detailed structures of RNA aptamer complexes with adenosine monophosphate (AMP), flavin mononucleotide (FMN), arginine/citrulline, and tobramycin are presented.
  • Insights into base-pair kinetics using hydrogen exchange for the AMP-RNA aptamer complex.
  • Identification of common principles and diversity in RNA architecture and molecular recognition.

Conclusions:

  • RNA aptamer structures reveal sophisticated molecular recognition and adaptive binding strategies.
  • Comparative analysis provides a framework for understanding RNA architecture and function.
  • These findings advance the knowledge of RNA-mediated molecular interactions.