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The CD40 pathway in allograft rejection, acceptance, and tolerance

C P Larsen1, T C Pearson

  • 1Emory University, Atlanta, GA 30322, USA. clarsen@emory.org

Current Opinion in Immunology
|November 22, 1997
PubMed

The CD40 pathway plays a critical role at many levels of the sensitization and effector phases of allograft rejection. In addition to the important signaling role of this pathway for T cell help and effector function, recent evidence suggests that the CD40 pathway can directly co-stimulate T cells, independently of its effect on the B7-CD28 pathway.

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