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Related Experiment Videos

Prospects for adoptive T cell therapy

C Yee1, S R Riddell, P D Greenberg

  • 1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA.

Current Opinion in Immunology
|November 22, 1997
PubMed
Summary
This summary is machine-generated.

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Researchers are identifying tumor antigens for cancer immunotherapy. Lessons from viral disease treatments will guide the development of T cell therapies for cancer patients.

Area of Science:

  • Immunology
  • Oncology
  • Translational Medicine

Background:

  • Methods for isolating genes encoding cytotoxic T lymphocyte (CTL) defined tumor antigens have been established.
  • Several tumor antigens have been identified and characterized for their potential as immunotherapy targets.

Purpose of the Study:

  • To review the progress in identifying and characterizing tumor antigens for immunotherapy.
  • To discuss strategies for generating T cells that target these antigens.
  • To leverage insights from adoptive immunotherapy of viral diseases to advance cancer immunotherapy.

Main Methods:

  • Review of established methods for gene isolation and antigen characterization.
  • Analysis of strategies for T cell generation.
  • Synthesis of data from clinical trials in viral diseases.

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Main Results:

  • Identification and characterization of multiple tumor antigens suitable for immunotherapy.
  • Development of innovative strategies for generating antigen-specific T cells.

Conclusions:

  • The established methods and identified antigens provide a foundation for cancer immunotherapy.
  • Lessons learned from viral disease immunotherapy trials are crucial for designing effective cancer treatment strategies.
  • Advancements are expected to facilitate the design of clinical trials for adoptive T cell immunotherapy of cancer.