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[Shear stress and platelet-derived microparticles]

S Nomura1, Y Komiyama

  • 1First Department of Internal Medicine, Kansai Medical University, Moriguchi.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|November 22, 1997
PubMed
Summary

High shear stress activates platelets, causing them to shed microparticles. These microparticles and remaining platelets exhibit procoagulant activity, contributing to arterial thrombosis in conditions like atherosclerosis.

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Area of Science:

  • Hematology
  • Biophysics

Context:

  • Platelets are crucial in hemostasis and thrombosis.
  • Pathological shear stress occurs in diseased arteries.
  • Platelet microparticles are implicated in various clinical conditions.

Purpose:

  • To investigate if high shear stress induces platelet aggregation and microparticle shedding.
  • To elucidate the mechanisms behind shear-induced microparticle generation.

Summary:

  • High shear stress applied via a cone-plate viscometer induced platelet aggregation and microparticle shedding.
  • Microparticle formation increased with shear stress duration.
  • Mechanisms involved von Willebrand factor, calcium influx, calpain activation, and protein kinase C.
  • Both microparticles and remnant platelets displayed procoagulant activity.

Impact:

  • Shear-induced microparticles contribute to arterial thrombosis by providing a procoagulant surface.
  • Findings are relevant to understanding thrombosis in atherosclerosis and vasospasm.
  • Highlights the role of platelet activation under pathological flow conditions.

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