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GLP-1 (7-36) amide: effects on glucose transport and metabolism in rat adipose tissue
A Perea1, C Viñambres, F Clemente
1Department of Metabolism, Nutrition and Hormones, Foundación Jiménez Díaz, Madrid, Spain.
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|November 25, 1997
Abstract:
In rat adipocytes, GLP-1 (7-36) amide induced an increment in 2-deoxy-glucose uptake, which was additive to that of insulin. Furthermore, in rat fat, GLP-1 (7-36) amide provoked a rise in glycogen synthesis, glucose oxidation and utilization and lipogenesis, the increments being lower than those obtained with insulin. These data support the idea that GLP-1 exerts insulin-like effects on glucose metabolism in rat adipose tissue, as it does in rat hepatocytes and skeletal muscle, although with a lower potency than that of insulin.