Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Increased plasma malondialdehyde associated with cerebellar structural defects

V T Ramaekers1, B Bosman, G A Jansen

  • 1Department of Paediatrics, University Hospital Aachen, Germany.

Archives of Disease in Childhood
|November 26, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Organization and integration of biomedical knowledge with concept maps for key peroxisomal pathways.

Bioinformatics (Oxford, England)·2008
Same author

A phytol-enriched diet induces changes in fatty acid metabolism in mice both via PPARalpha-dependent and -independent pathways.

Journal of lipid research·2005
Same author

Refsum disease, peroxisomes and phytanic acid oxidation: a review.

Journal of neuropathology and experimental neurology·2001
Same author

Peroxisomal fatty acid alpha- and beta-oxidation in humans: enzymology, peroxisomal metabolite transporters and peroxisomal diseases.

Biochemical Society transactions·2001
Same author

Identification of pristanal dehydrogenase activity in peroxisomes: conclusive evidence that the complete phytanic acid alpha-oxidation pathway is localized in peroxisomes.

Biochemical and biophysical research communications·2001
Same author

Etherphospholipid biosynthesis and dihydroxyactetone-phosphate acyltransferase: resolution of the genomic organization of the human gnpat gene and its use in the identification of novel mutations.

Biochemical and biophysical research communications·2001

Children with pontocerebellar structural defects show elevated malondialdehyde (MDA) levels, indicating increased lipid peroxidation. This suggests MDA may play a role in prenatal and postnatal brain development issues.

Area of Science:

  • Biochemistry
  • Pediatric Neurology
  • Developmental Biology

Background:

  • Malondialdehyde (MDA) is a key biomarker for lipid peroxidation.
  • Elevated MDA levels suggest oxidative stress and cellular damage.

Purpose of the Study:

  • To investigate plasma MDA concentrations in children with pontocerebellar structural defects.
  • To compare MDA levels between these children and healthy controls or those with other neurological disorders.

Main Methods:

  • Plasma MDA concentrations were measured in three groups: healthy children, children with neurological disorders/epilepsy, and children with pontocerebellar structural defects.
  • Statistical comparison of MDA levels across the groups.

Main Results:

Related Experiment Videos

  • Healthy children had a median MDA of 5.86 nmol/ml.
  • Children with neurological disorders/epilepsy showed similar MDA levels (median 5.66 nmol/ml).
  • Children with pontocerebellar structural defects exhibited significantly higher MDA levels (median 11.29 nmol/ml).

    • Conclusions:

    • Increased plasma MDA is prevalent in children with pontocerebellar structural defects of unknown origin.
    • This finding raises questions about the role of lipid peroxidation in pontocerebellar maldevelopment or degeneration.