Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chemoattractant receptors

H D Perez1

  • 1Berlex Biosciences, Richmond, California, USA.

Current Opinion in Hematology
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Cell migration during inflammation relies on chemotactic factors binding to leukocyte receptors. Understanding these structure-function relationships offers new therapeutic targets for inflammatory diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CCR1-specific non-peptide antagonist: efficacy in a rabbit allograft rejection model.

Immunology letters·2001
Same author

A non-peptide functional antagonist of the CCR1 chemokine receptor is effective in rat heart transplant rejection.

The Journal of biological chemistry·2000
Same author

Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor.

Journal of immunology (Baltimore, Md. : 1950)·2000
Same author

The type IV phosphodiesterase specific inhibitor mesopram inhibits experimental autoimmune encephalomyelitis in rodents.

Journal of neuroimmunology·2000
Same author

Role of the intracellular domain of the human type I interferon receptor 2 chain (IFNAR2c) in interferon signaling. Expression of IFNAR2c truncation mutants in U5A cells.

The Journal of biological chemistry·2000
Same author

Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1.

The Journal of biological chemistry·2000

Area of Science:

  • Immunology
  • Cell Biology
  • Pharmacology

Background:

  • Inflammation involves cellular responses, notably cell migration guided by chemical signals called chemotactic factors.
  • Chemotactic factors act as ligands, binding to specific cell surface receptors to trigger cellular events.
  • These events include cell migration, adhesion, and activation, crucial for the inflammatory process.

Purpose of the Study:

  • To review recent advancements in understanding the structure-function relationships of chemotactic factor receptors on human leukocytes.
  • To identify potential targets for pharmacological intervention within these receptor systems.

Main Methods:

  • Literature review of recent studies on chemotactic factor receptors.
  • Analysis of structure-function relationships in human leukocyte chemotactic factor receptors.

Related Experiment Videos

  • Exploration of potential pharmacological intervention points.

    • Main Results:

    • Recent advances have elucidated complex structure-function relationships of chemotactic factor receptors.
    • Specific receptor-ligand interactions are key to initiating inflammatory cell responses.
    • Potential strategies for modulating these interactions for therapeutic benefit have been identified.

    Conclusions:

    • Detailed knowledge of chemotactic factor receptor structure-function is critical for understanding leukocyte behavior in inflammation.
    • Targeting these receptors offers promising avenues for developing novel anti-inflammatory therapies.