Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hematopoietic cell proliferation and differentiation

C A Sieff1

  • 1Division of Hematology and Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Current Opinion in Hematology
|July 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence for linkage of familial Diamond-Blackfan anemia to chromosome 8p23.3-p22 and for non-19q non-8p disease.

Blood·2001
Same author

Congenital bone marrow failure syndromes.

British journal of haematology·2000
Same author

Maturation and lineage-specific expression of the coxsackie and adenovirus receptor in hematopoietic cells.

Stem cells (Dayton, Ohio)·2000
Same author

Diamond-Blackfan anemia.

Current opinion in hematology·2000
Same author

Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP.

Genes & development·2000
Same author

Essential role for the p55 tumor necrosis factor receptor in regulating hematopoiesis at a stem cell level.

The Journal of experimental medicine·1999
Same journal

Dynamic myeloid suppressor states in cancer and inflammation and their therapeutic potential.

Current opinion in hematology·2026
Same journal

Factor XIa inhibition for the prevention of thrombosis: mechanism, clinical trial signals, and indication-specific positioning.

Current opinion in hematology·2026
Same journal

Nutrition as a regulator of hematopoietic stem cell biology and transplantation.

Current opinion in hematology·2026
Same journal

From biomimicry to clinical actionability: rethinking high-shear thrombosis as a mechanobiological system.

Current opinion in hematology·2026
Same journal

Bidirectional relationship between metabolic and thrombotic disease mechanisms.

Current opinion in hematology·2026
Same journal

The dual role of the brain-derived neurotrophic factor as a regulator of hemostasis and thrombotic risk.

Current opinion in hematology·2026
See all related articles

Hematopoietic growth factors regulate blood cell development by stimulating stem cell division and progenitor proliferation. These factors influence cell survival and differentiation through complex signaling pathways and transcription factors.

Area of Science:

  • Hematology
  • Cell Biology
  • Molecular Biology

Background:

  • Hematopoietic stem cells (HSCs) are typically quiescent in the G0 phase.
  • Hematopoietic growth factors (HGFs) are crucial for regulating blood cell production.

Purpose of the Study:

  • To elucidate the mechanisms by which HGFs regulate HSCs and progenitor cells.
  • To explore the role of HGFs in cell cycle regulation, survival, proliferation, and differentiation.

Main Methods:

  • Analysis of HGF binding to cognate receptors on stem cells.
  • Investigation of signal transduction pathways activated by HGF receptors, including tyrosine kinases and Ras.
  • Examination of transcription factor activation and nuclear translocation.
  • Study of "master" transcription factors regulating hematopoietic lineage commitment.

Related Experiment Videos

Main Results:

  • HGFs can shorten the G0 phase of HSCs, promoting cell division.
  • HGFs enhance survival and proliferation of committed progenitors, amplifying maturing cell populations.
  • Evidence suggests HGF receptors on mature cells may direct differentiation, though this is debated.
  • HGF signaling involves overlapping tyrosine kinases and common pathways like Ras.
  • HGFs activate cytoplasmic transcription factors that translocate to the nucleus.
  • Lineage-specific differentiation is controlled by "master" transcription factors.

Conclusions:

  • HGFs play a multifaceted role in hematopoiesis, controlling stem cell cycling, progenitor expansion, and potentially differentiation.
  • Complex intracellular signaling cascades and transcription factor networks mediate the effects of HGFs.
  • The precise role of HGFs in differentiation and apoptosis prevention requires further investigation.