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New markers for in vivo coagulation
1Beth Israel Hospital, Molecular Medicine Department, Boston, MA 02215, USA.
Current Opinion in Hematology
|September 1, 1994
Summary
Biochemical markers can detect imbalances in blood coagulation before thrombosis occurs. Further research is needed to confirm if these assays can identify individuals at risk for hypercoagulable states and guide preventative therapy.
Area of Science:
- Biochemistry
- Hematology
- Thrombosis Research
Background:
- Understanding the biochemistry of hemostasis has advanced.
- Sensitive measurement methods for coagulation system activation markers have been developed.
Purpose of the Study:
- To explore the utility of biochemical markers in detecting hypercoagulable states.
- To assess the potential for early intervention in thrombotic disease.
Main Methods:
- Utilized sensitive assays to measure peptides, enzyme-inhibitor complexes, and enzymes.
- These markers are associated with the in vivo activation of the coagulation system.
Main Results:
- Biochemical imbalances between procoagulant and anticoagulant mechanisms were detected in human blood.
- These imbalances were observed prior to the clinical manifestation of thrombotic phenomena.
Conclusions:
- Biochemical markers may indicate a hypercoagulable state before overt thrombotic disease.
- Prospective studies are necessary to validate these assay techniques for clinical risk assessment and intervention.