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Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa
T Köhler1, M Michea-Hamzehpour, P Plesiat
1Department of Genetics and Microbiology, Centre Médical Universitaire, Geneva, Switzerland. Thilo.Kohler@medecine.unige.ch
Antimicrobial Agents and Chemotherapy
|November 26, 1997
Abstract:
Resistance mechanisms selected after in vitro exposure to 12 quinolones were analyzed for Pseudomonas aeruginosa. Efflux-type mutants were predominant. Quinolones differed in their ability to select a particular efflux system. While the newer fluoroquinolones favored the MexCD-OprJ system, the older quinolones selected exclusively the MexEF-OprN or MexAB-OprM systems. A protonable C-7 substituent in combination with a C-6 fluorine atom is a structural determinant of quinolones involved in efflux pump substrate specificity.