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Diazepam-mediated inhibition of human immunodeficiency virus type 1 expression in human brain cells
J R Lokensgard1, G Gekker, S Hu
1Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, Minnesota 55404, USA.
Antimicrobial Agents and Chemotherapy
|November 26, 1997
Abstract:
Treatment of acutely infected human brain cell and enriched microglial cell cultures with diazepam inhibited human immunodeficiency virus type 1 (HIV-1) p24 antigen expression. Similarly, diazepam suppressed HIV-1 expression in chronically infected promonocytic (U1) cells and acutely infected monocyte-derived macrophages, and this antiviral activity was associated with decreased activation of nuclear factor kappa B.

