Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The L-selectin adhesion system

I Stamenkovic1

  • 1Harvard Medical School, Boston, Massachusetts, USA.

Current Opinion in Hematology
|January 1, 1995
PubMed
Summary

L-selectin, a key cell surface glycoprotein, mediates leukocyte interactions in lymphoid tissues and at inflammatory sites. Its calcium-dependent lectin function is crucial for both normal physiological processes and pathological conditions, as recent studies show.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sarcomas: genetics, signalling, and cellular origins. Part 2: TET-independent fusion proteins and receptor tyrosine kinase mutations.

The Journal of pathology·2007
Same author

Sarcomas: genetics, signalling, and cellular origins. Part 1: The fellowship of TET.

The Journal of pathology·2007
Same author

Exogenous mesenchymal stem cells localize to the kidney by means of CD44 following acute tubular injury.

Kidney international·2007
Same author

Inhibition of the hyaluronan-CD44 interaction by merlin contributes to the tumor-suppressor activity of merlin.

Oncogene·2006
Same author

A gene expression signature that distinguishes desmoid tumours from nodular fasciitis.

The Journal of pathology·2006
Same author

Analysis of reactive oxygen species in cell death.

Methods in cell biology·2001

Area of Science:

  • Immunology
  • Cell Biology
  • Biochemistry

Background:

  • L-selectin is a cell surface glycoprotein found on most leukocytes.
  • It plays a critical role in leukocyte adhesion to endothelial cells.
  • L-selectin functions as a calcium-dependent lectin, binding to specific carbohydrate ligands.

Purpose of the Study:

  • To highlight the function of L-selectin in leukocyte trafficking.
  • To emphasize the role of L-selectin in both normal physiology and disease pathogenesis.
  • To summarize recent findings on L-selectin's in vivo importance.

Main Methods:

  • Review of recent in vivo studies.
  • Analysis of L-selectin's molecular function as a lectin.
  • Examination of L-selectin's role in leukocyte-endothelial interactions.

Main Results:

  • L-selectin mediates leukocyte adhesion to high endothelial venules in lymphoid organs.
  • It also facilitates leukocyte interaction with activated endothelium at inflammatory sites.
  • In vivo studies confirm the significance of L-selectin expression in various conditions.

Conclusions:

  • L-selectin is essential for leukocyte homing and inflammatory responses.
  • Its lectin activity is critical for recognizing carbohydrate ligands.
  • Understanding L-selectin's function is vital for both normal biological processes and disease management.

Related Experiment Videos