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Related Experiment Videos

Update on development of interleukin-11

X Du1, D A Williams

  • 1Herman B Wells Center for Pediatric Research, Riley Hospital for Children, Indianapolis, Indiana, USA.

Current Opinion in Hematology
|May 1, 1995
PubMed
Summary

Interleukin-11 (IL-11) shows promise in cancer therapy by accelerating recovery of blood and gut cells. Clinical studies indicate IL-11 is well-tolerated and may prevent chemotherapy-induced neutropenia and thrombocytopenia.

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Area of Science:

  • Immunology
  • Molecular Biology
  • Oncology

Background:

  • Interleukin-11 (IL-11) is a cytokine produced by mesenchymal cells.
  • Its gene expression is influenced by inflammatory cytokines and agonists.
  • Signaling pathways for IL-11 gene induction differ across cell types.

Purpose of the Study:

  • To review recent research on interleukin-11 (IL-11).
  • To cover IL-11 gene expression, regulation, receptor, and signaling.
  • To summarize pharmacologic effects and clinical studies of IL-11.

Main Methods:

  • Review of recent scientific literature on interleukin-11.
  • Analysis of in vitro and in vivo preclinical studies.
  • Evaluation of data from human clinical trials.

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Main Results:

  • IL-11 exhibits diverse bioactivities in both hematopoietic and non-hematopoietic cells.
  • Preclinical models suggest IL-11 aids recovery of hematopoietic and gastrointestinal cells post-therapy.
  • Clinical trials show IL-11 is well-tolerated.

Conclusions:

  • Interleukin-11 (IL-11) demonstrates potential therapeutic benefits.
  • IL-11 may be effective in preventing neutropenia and thrombocytopenia in cancer patients undergoing chemotherapy.