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Changing concepts in fibrinolysis

¹Department of Pediatrics, Cornell University Medical College, New York, NY 10021, USA.

Current Opinion in Hematology

|September 1, 1995

Summary

Recent molecular biology advances are reshaping fibrinolysis understanding. New receptors and plasminogen/apolipoprotein(a) homologues suggest novel pathways for generating the protease plasmin.

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Area of Science:

Molecular Biology
Biochemistry
Physiology

Background:

Traditional fibrinolysis concepts are being reevaluated.
Advances in molecular biology necessitate a review of existing knowledge.

Purpose of the Study:

To explore new potential mechanisms for controlled plasmin generation.
To integrate recent findings in molecular biology with fibrinolysis research.

Main Methods:

Identification of novel cell surface activation receptors.
Characterization of plasminogen/apolipoprotein(a) homologues.

Main Results:

Novel cell surface receptors implicated in fibrinolysis.
Discovery of plasminogen/apolipoprotein(a) homologues with potential roles.

Conclusions:

New molecular discoveries offer alternative pathways for plasmin generation.
These findings suggest a revised framework for understanding fibrinolysis.

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