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Related Experiment Videos

Apoptotic signaling in lymphocytes

C M Rudin1, J Van Dongen, C B Thompson

  • 1Gwenn Knapp Center for Lupus and Immunology Research, University of Chicago, IL 60637-5420, USA.

Current Opinion in Hematology
|January 1, 1996
PubMed
Summary

Lymphocyte survival and apoptosis are regulated by the tumor necrosis factor receptor and CD28/CTLA4 families. These cell surface receptors control immune responses and T-cell fate, impacting autoimmune disease understanding.

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Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Cell surface receptors critically regulate lymphocyte survival and programmed cell death (apoptosis).
  • Key families involved include the tumor necrosis factor receptor (TNFR) family and the CD28/CTLA4 family.
  • TNFR family members bind tumor necrosis factor (TNF) ligands, influencing cell death induction or inhibition.

Purpose of the Study:

  • To elucidate the roles of TNFR and CD28/CTLA4 families in lymphocyte apoptosis.
  • To understand the signaling mechanisms and cytoplasmic proteins involved in receptor-mediated apoptosis.
  • To explore how these pathways contribute to immune response termination and T-cell homeostasis.

Main Methods:

  • Identification and characterization of cytoplasmic proteins involved in TNFR and CD28/CTLA4 signaling.

Related Experiment Videos

  • Analysis of structural motifs in signaling proteins.
  • Investigating the dependence of CD28/CTLA4 effects on T-cell antigen receptor engagement.

    • Main Results:

    • Two TNFR members, TNFR1 and Fas, are implicated in immune response termination via apoptosis.
    • Cytoplasmic proteins with shared structural motifs have been identified in signaling pathways.
    • CD28 and CTLA4 signaling influences T-cell apoptotic sensitivity, dependent on T-cell antigen receptor engagement.

    Conclusions:

    • TNFR and CD28/CTLA4 signaling pathways are crucial for regulating T-cell survival and apoptosis.
    • These pathways provide mechanisms for clonal T-cell expansion or deletion.
    • Studying lymphocyte apoptosis offers insights into autoimmune disease and tissue homeostasis.