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Published on: February 19, 2017
Treatment of sickling disorders
1Johns Hopkins University, Baltimore, MD 21209-4519, USA.
Current Opinion in Hematology
|March 1, 1996
Summary
Sudden death in military recruits with sickle cell trait is linked to heat and preventable with precautions. Sickle cell disease treatments focus on reducing sickle cells, but long-term strategies require further understanding.
Area of Science:
- Hematology
- Military Medicine
- Preventive Medicine
Background:
- Sudden death in military recruits is associated with sickle cell trait.
- Hyperthermia is a likely contributing factor to these deaths.
- Current treatments for sickle cell disease involve transfusions to reduce sickle cells.
Purpose of the Study:
- To explore the link between sickle cell trait and sudden death in recruits.
- To understand the mechanisms and potential prevention of sickle cell disease.
- To review current and emerging treatment strategies for sickle cell disease.
Main Methods:
- Review of cases involving sudden death in military recruits with sickle cell trait.
- Analysis of the pathophysiology of sickle cell disease.
- Evaluation of transfusion therapy for sickle cell disease.
- Exploration of methods to prevent erythrocyte sickling.
Main Results:
- Sudden death in recruits with sickle cell trait is likely due to hyperthermia.
- Preventive measures and awareness can mitigate this risk.
- Transfusion therapy is a treatment option for sickle cell disease, with evolving indications and understanding of its pathophysiology.
- Methods like stimulating fetal hemoglobin production are being investigated to prevent sickling, but their risks and benefits are not fully understood.
Conclusions:
- Heightened awareness and precautions can prevent heat-related deaths in military recruits with sickle cell trait.
- Further research is needed to fully understand the risks and benefits of novel treatments aimed at preventing erythrocyte sickling in sickle cell disease.
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