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Related Experiment Videos

Laboratory testing for hypercoagulable disorders

M P Jones1, B Alving

  • 1Hematology/Oncology Service, Walter Reed Army Medical Center, Washington, DC, USA.

Current Opinion in Hematology
|September 1, 1996
PubMed
Summary
This summary is machine-generated.

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Testing for inherited hypercoagulability in venous thromboembolism patients involves assessing protein S, protein C, and antithrombin III levels. These cost-effective tests aid patient management and family care in high-risk situations.

Area of Science:

  • Hematology
  • Genetics
  • Clinical Medicine

Background:

  • Inherited hypercoagulability contributes to venous thromboembolism (VTE).
  • Evaluation includes testing for protein S, protein C, antithrombin III, and activated protein C resistance.
  • Acquired disorders like antiphospholipid syndrome also cause thrombosis.

Purpose of the Study:

  • To outline the diagnostic approach for inherited and acquired hypercoagulable states in VTE patients.
  • To highlight the clinical relevance and cost-effectiveness of thrombophilia testing.

Main Methods:

  • Functional assays for protein S, protein C, and antithrombin III.
  • Plasma-based and DNA-based assays for activated protein C resistance.
  • Clinical assessment for risk factors (e.g., oral contraceptives, trauma).

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Main Results:

  • Inherited and acquired thrombophilia are often seen in younger VTE patients with additional risk factors.
  • Testing identifies specific deficiencies or resistance linked to thrombosis.
  • Diagnostic tests are commercially available.

Conclusions:

  • Thrombophilia testing is valuable for guiding patient management.
  • Results can inform risk assessment and care for family members.
  • Testing is cost-effective when it influences clinical decisions.