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Related Experiment Videos

Therapeutic plasmapheresis

G Rock1, N A Buskard

  • 1University of Ottawa, Ontario, Canada.

Current Opinion in Hematology
|November 1, 1996
PubMed
Summary
This summary is machine-generated.

Plasma exchange (PE) is a therapeutic apheresis technique used for various neurological disorders and autoimmune conditions. While beneficial, its optimal use and comparative efficacy against other treatments like intravenous immunoglobulin remain under investigation.

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Area of Science:

  • Therapeutic Apheresis
  • Neurology
  • Immunology

Background:

  • Plasma exchange (PE) has been extensively studied for 25 years to establish its therapeutic applications.
  • PE is widely used for neurological disorders like Guillain-Barré syndrome, often combined with intravenous immunoglobulin (IVIg).
  • Its efficacy in neuropathies and vasculitides is also recognized, though optimal treatment strategies are still evolving.

Purpose of the Study:

  • To review the established and emerging applications of plasma exchange in various medical conditions.
  • To assess the current understanding of PE's benefits, alone or in combination with other therapies.
  • To highlight newer modifications and future therapeutic potentials of PE.

Main Methods:

  • Review of clinical data and trial outcomes related to plasma exchange applications.

Related Experiment Videos

  • Assessment of therapeutic efficacy in neurologic disorders, autoimmune diseases, and organ failure.
  • Evaluation of modified PE techniques, such as photopheresis.

    • Main Results:

    • PE, often with IVIg, shows benefits in Guillain-Barré syndrome, but relative advantages are unclear.
    • Improved outcomes in thrombotic thrombocytopenic purpura (TTP) with cryosupernatant, yet mortality remains high.
    • Variable responses to PE observed in Hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome, organ failure, and transplant rejection.

    Conclusions:

    • Plasma exchange is a valuable therapeutic tool with established roles in various conditions.
    • Ongoing research is refining PE applications and exploring innovative modifications like photopheresis.
    • The field of therapeutic apheresis continues to advance, offering new treatment opportunities.