Related Experiment Videos
Interactions of some PGHS-2 selective inhibitors with the PGHS-1: an automated docking study by BioDock
A Pedretti1, A M Villa, L Villa
1Istituto di Chimica Farmaceutica, Università di Milano, Milano.
Farmaco (Societa Chimica Italiana : 1989)
|June 1, 1997
Abstract:
The automated stochastic docking procedure BioDock has been applied to a series of inhibitors of PGH synthase, the key enzyme in the synthesis of eicosanoids from arachidonic acid. Some PGHS-2 selective inhibitors have been docked to the structure of the ovine PGHS-1 enzyme, as recently obtained by means of X-ray crystallographic analysis, in order to highlight possible structural bases for selectivity.