Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serum albumin. A CAP survey

J G Batsakis, R S Aronsohn, W A Walker

    American Journal of Clinical Pathology
    |July 1, 1976
    PubMed
    Summary

    A 1974 survey revealed that most labs used dye-binding methods for albumin measurement. Despite variations, methods showed comparable results, with standardization type not impacting albumin estimation in normal serum.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Analytical Bayesian approach for the design of surveillance and control programs to assess pest-eradication success.

    Theoretical population biology·2022
    Same author

    Power on: The rapid transition of a large interdisciplinary behavioral health department to telemental health during the COVID-19 pandemic.

    Journal of interprofessional education & practice·2022
    Same author

    Analytical Bayesian models to quantify pest eradication success or species absence using zero-sighting records.

    Theoretical population biology·2021
    Same author

    Modelling the impact of biosecurity practices on the risk of high pathogenic avian influenza outbreaks in Australian commercial chicken farms.

    Preventive veterinary medicine·2019
    Same author

    Targeted methylation sequencing of plasma cell-free DNA for cancer detection and classification.

    Annals of oncology : official journal of the European Society for Medical Oncology·2018
    Same author

    How to defuse a demographic time bomb: the way forward?

    Eye (London, England)·2017

    Area of Science:

    • Clinical Chemistry
    • Laboratory Medicine
    • Biochemical Analysis

    Background:

    • Albumin measurements are crucial in clinical diagnostics.
    • Standardization of laboratory methods is essential for reliable results.
    • Variability in albumin assays can impact patient care.

    Purpose of the Study:

    • To assess albumin measurement methods used by clinical laboratories in 1974.
    • To compare the accuracy and interlaboratory variability of different albumin assay techniques.
    • To evaluate the influence of standardization materials on albumin concentration determination.

    Main Methods:

    • Survey of over 1,300 laboratories regarding their albumin measurement techniques.
    • Analysis of data from dye-binding methods (bromcresol green and HABA), electrophoresis, and salt fractionation.
    • Comparison of albumin concentration results across different methods and standardization types.

    Main Results:

    • Dye-binding methods (BCG and HABA) were most prevalent.
    • Electrophoresis showed a consistent low bias compared to other methods.
    • Interlaboratory variation was lowest for salt fractionation and electrophoresis.
    • Standardization type did not significantly affect albumin estimation in normal serum.

    Conclusions:

    • Most common albumin assays demonstrated comparable results for normal serum.
    • Electrophoresis exhibited a systematic underestimation of albumin.
    • Salt fractionation and electrophoresis showed the least interlaboratory variability.
    • Further investigation into standardization practices may be warranted for specific assays.

    Related Experiment Videos