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Orbital hemangiopericytoma: clinical and morphologic features
Z A Karcioglu1, A M Nasr, B G Haik
1Tulane University Medical School, New Orleans, Louisiana, USA.
American Journal of Ophthalmology
|December 31, 1997
Summary
Orbital hemangiopericytoma can behave aggressively, causing recurrence and metastasis. Joint clinical and histopathologic evaluation is crucial for predicting the tumor's behavior.
Area of Science:
- Ophthalmology
- Pathology
- Oncology
Background:
- Orbital hemangiopericytoma is a rare vascular tumor.
- Understanding its clinical and histopathologic features is essential for diagnosis and management.
Purpose of the Study:
- To describe the clinical and histopathologic characteristics of orbital hemangiopericytoma.
- To correlate these features with patient outcomes.
Main Methods:
- Retrospective review of seven patients with orbital hemangiopericytoma.
- Analysis of clinical data, imaging (ultrasonography, CT, MRI), and histopathologic findings.
- Evaluation of treatment modalities and patient follow-up.
Main Results:
- Imaging studies defined tumor extent but lacked pathognomonic features for hemangiopericytoma.
- Histopathology revealed a mixed pattern of ovoid cells and sinusoidal spaces, with cellular atypia and mitotic activity in some cases.
- Treatment included surgery and radiation therapy; three patients experienced recurrence and metastasis, while four remained disease-free after 3-9 years.
Conclusions:
- Orbital hemangiopericytoma can exhibit malignant behavior with local recurrence and/or metastasis.
- Prognosis depends on a combination of clinical and histopathologic factors.
- Histopathology alone is insufficient to predict the tumor's biologic behavior.