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Association of pseudoexfoliation syndrome with increased vascular risk
P Mitchell1, J J Wang, W Smith
1Department of Ophthalmology, University of Sydney, NSW, Australia. paulmi@westmed.wh.su.edu.au
Purpose:
To examine vascular associations with pseudoexfoliation syndrome in view of the wide-spread elastosis now demonstrated in this disorder that affects many tissues, including vessel walls.
Methods:
The Blue Mountains Eye Study is a population-based study of eye disease in an area west of Sydney, Australia. Of 4433 eligible persons aged 49 years or older, 3,654 (82.4%) participated. Signs of pseudoexfoliation were graded clinically, after excluding 108 people who had bilateral cataract surgery.
Results:
Pseudoexfoliation was present in 81 (2.3%) of 3546 participants aged 49 years or older. The prevalence of pseudoexfoliation increased with age and was higher in women and in people with glaucoma. Pseudoexfoliation was statistically significantly associated with a history of angina or hypertension or a combined history of angina, acute myocardial infarction, or stroke.
Conclusion:
Slit-lamp signs of pseudoexfoliation may identify individuals with an increased vascular risk.
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