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Updated: Aug 19, 2026

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
Primary transitional cell carcinoma in vesical diverticula
1Department of Urology, Rabin Medical Center (Beilinson Campus), Petach Tikva, Israel.
Objectives:
To evaluate the treatment and prognosis of primary tumors in bladder diverticula.
Methods:
The cases of 611 patients treated for bladder tumors at a single medical center were retrospectively reviewed.
Results:
Eight patients had primary intradiverticular transitional cell carcinoma. Five patients had Stage Ta tumor, and 3 had Stage T1 tumor. Most patients were treated by local resection and adjuvant intravesical chemotherapy. All patients with initial Ta disease are disease free at the time of this writing. One patient with T1 disease died, 1 patient's disease recurred several times, and 1 patient showed positive cytology without apparent disease.
Conclusions:
Superficial intradiverticular tumors may be treated conservatively. Routine cystoscopy for patients with a bladder diverticulum is warranted for early diagnosis of possible intradiverticular tumor.
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