Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Urea kinetic modeling for CRRT

L Garred1, M Leblanc, B Canaud

  • 1Department of Chemical Engineering, Lakehead University, Thunder Bay, Ontario, Canada. laurie.garred@lakeheadu.ca

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|December 31, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Competition between merging and bifurcation in the generalized Rayleigh-Taylor instability.

Physical review. E·2024
Same author

Solid-to-plasma transition of polystyrene induced by a nanosecond laser pulse within the context of inertial confinement fusion.

Physical review. E·2024
Same author

High-Target Hemodiafiltration Convective Dose Achieved in Most Patients in a 6-Month Intermediary Analysis of the CONVINCE Randomized Controlled Trial.

Kidney international reports·2023
Same author

Partition of Omega-like facility into two configurations of 24 and 36 laser beams to improve implosion performance.

Scientific reports·2023
Same author

Effect of collisions with a second fluid on the temporal development of nonlinear, single-mode, Rayleigh-Taylor instability.

Physical review. E·2022
Same author

Clinical outcomes of hemodialysis patients in a public-private partnership care framework in Italy: a retrospective cohort study.

BMC nephrology·2019
Same journal

Approach to Hyperkalemia: The Role of Diet and Pharmacological Therapies.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

High Protein Diets: What to Tell Our Patients.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Progressive Kidney Dysfunction and Ocular Clues: A Quiz.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Influence of Lactate Dehydrogenase on the Measurement of Blood Bicarbonate.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Urinary CXCL9 and CXCL10, Interstitial Inflammation and Disease Activity Over Time in Acute Interstitial Nephritis.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Hemophagocytic Lymphohistiocytosis and Fibroblast Growth Factor 23 (FGF23)-Induced Hypophosphatemia.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
See all related articles

Urea kinetic modeling (UKM) provides a quantitative method for prescribing continuous renal replacement therapies (CRRTs) in acute renal failure (ARF). This approach helps achieve target blood urea nitrogen (BUN) levels, optimizing dialysis treatment for critically ill patients.

Area of Science:

  • Nephrology
  • Critical Care Medicine
  • Biomedical Engineering

Background:

  • Urea kinetic modeling (UKM) is established for chronic renal failure (CRF) but underutilized in acute renal failure (ARF).
  • Accurate prescription of continuous renal replacement therapies (CRRTs) is crucial for managing ARF.
  • Current CRRT prescription methods in ARF often lack quantitative rigor.

Purpose of the Study:

  • To present a quantitative UKM-based approach for prescribing CRRTs in ARF.
  • To establish methods for calculating necessary CRRT clearance (K) to achieve target blood urea nitrogen (BUN) levels.
  • To propose urea mass balance equations for determining patient urea generation rate (G).

Main Methods:

  • Utilized UKM principles to model BUN decline during CRRT.

Related Experiment Videos

  • Derived formulas for CRRT clearance (K) based on urea generation rate (G) and desired BUN (Cgoal).
  • Proposed urea mass balance equations for estimating patient G during BUN changes.
  • Developed a practical CRRT prescription guideline for estimating K in the absence of precise G.

    • Main Results:

    • BUN levels decrease exponentially during CRRT, reaching a plateau.
    • CRRT clearance (K) required to achieve a target BUN (Cgoal) can be calculated using G/Cgoal.
    • A simplified formula for K is proposed: 1.2 * (patient weight in kg) / (Cgoal in mg/dL) for moderate hypercatabolism.

    Conclusions:

    • UKM offers a robust framework for quantitative CRRT prescription in ARF.
    • The proposed methods and simplified formula provide practical tools for clinicians.
    • Optimized CRRT dosing based on UKM can improve patient outcomes in ARF.