Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Down syndrome and ionizing radiation

P Verger1

  • 1Institut de Protection et de Sûreté Nucléaire, Département de Protection de la santé de l'Homme et de Dosimétrie, Fontenay-aux Roses, France.

Health Physics
|December 31, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"<i>We don't have the same bodies; we don't react the same way</i>": mothers and adolescent girls' perceptions of the risks and benefits of HPV vaccination in France.

Human vaccines & immunotherapeutics·2022
Same author

'I trust them because my mum trusts them': Exploring the role of trust in HPV vaccination decision-making among adolescent girls and their mothers in France.

Vaccine·2022
Same author

The role of maturity in adolescent decision-making around HPV vaccination in France.

Vaccine·2021
Same author

Revue d'epidemiologie et de sante publique·2021
Same author

[The impact of the COVID-19 pandemic on first-line primary care in southeastern France: Feedback on the implementation of a real-time monitoring system based on regional health insurance data].

Revue d'epidemiologie et de sante publique·2021
Same author

What could explain the late emergence of COVID-19 in Africa?

New microbes and new infections·2020

Ionizing radiation may increase the risk of Down Syndrome (trisomy 21), particularly due to oocyte exposure around ovulation. Further research is needed to confirm this link and explore risks from artificial radiation sources.

Area of Science:

  • Genetics
  • Radiation Biology
  • Epidemiology

Background:

  • Down Syndrome (trisomy 21) is primarily caused by chromosome 21 nondisjunction, often in the oocyte.
  • Oocytes can be exposed to ionizing radiation during critical meiotic and periovulatory periods.
  • A reported temporal cluster of Down Syndrome cases post-Chernobyl highlights potential radiation links.

Purpose of the Study:

  • To review epidemiologic and experimental evidence on ionizing radiation's role in Down Syndrome.
  • To assess the risk of Down Syndrome associated with radiation exposure, particularly around ovulation.
  • To identify limitations in current research and propose future study directions.

Main Methods:

  • Review of existing epidemiologic studies on trisomies and radiation exposure.

Related Experiment Videos

  • Analysis of experimental studies investigating radiation-induced nondisjunction in gametogenesis.
  • Discussion of methodological challenges in Down Syndrome risk factor research.

    • Main Results:

    • Epidemiologic data suggest ionizing radiation cannot be excluded as a Down Syndrome risk factor.
    • Experimental studies show irradiation can induce nondisjunction, but human extrapolation is difficult.
    • Existing studies often overlook critical exposure periods and spontaneous abortion cases.

    Conclusions:

    • The potential link between ionizing radiation and Down Syndrome warrants further investigation.
    • New studies focusing on prolonged or repeated artificial radiation exposure in women are recommended.
    • Improved methodologies are needed to accurately assess Down Syndrome risk factors.