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TNF-alpha induces apoptosis in rat fetal brown adipocytes in primary culture
A Porras1, A M Alvarez, A Valladares
1Departamento de Bioquímica y Biología Molecular II, Instituto de Bioquímica, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
FEBS Letters
|December 31, 1997
Abstract:
The effect of TNF-alpha on cell death in rat fetal brown adipocytes maintained in primary culture was determined. TNF-alpha inhibited proliferation and induced apoptosis in these cells. Most of the cells undergoing apoptosis after TNF-alpha treatment did not express PCNA, suggesting an induction of apoptosis by TNF-alpha in non-proliferative cells. IGF-I but not EGF prevented TNF-alpha-induced apoptosis.