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Bone mineral density in Turner's syndrome--a longitudinal study
N J Shaw1, V K Rehan, S Husain
1Department of Growth and Endocrinology, Birmingham Children's Hospital, UK.
Clinical Endocrinology
|November 28, 1997
Summary
Bone density in girls with Turner syndrome is generally normal. Early estrogen replacement is not recommended as treatments showed no benefit in bone mineralization.
Area of Science:
- Pediatric Endocrinology
- Bone Metabolism
- Genetics
Background:
- Turner syndrome is associated with osteoporosis in adult women, but the underlying causes are not fully understood.
- Longitudinal bone health in pediatric populations with Turner syndrome requires further investigation.
Purpose of the Study:
- To longitudinally assess bone mineralization in girls with Turner syndrome.
- To evaluate the impact of various treatments on bone mineral density in this cohort.
Main Methods:
- Prospective observational study design.
- Inclusion of eighteen girls (aged 4-17 years) diagnosed with Turner syndrome.
- Dual-energy X-ray absorptiometry (DXA) used for lumbar spine bone mineral density assessment over 2.5 years.
Main Results:
- Only one participant exhibited a significant decrease in bone density, relative to body weight and pubertal status.
- No observed treatment demonstrated a clear advantage in improving bone mineralization.
Conclusions:
- Limited evidence of reduced bone mineral density in girls with Turner syndrome.
- No justification for early estrogen replacement therapy during prepubertal years based on current findings.