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The investigation and treatment of renal bone disease

G R Catto, M MacLeod

    The American Journal of Medicine
    |July 1, 1976
    PubMed

    Insights

    Neutron activation analysis monitored skeletal calcium in hemodialysis patients. Magnesium and oral calcium reduced calcium loss, while a vitamin D analogue increased bone calcium, potentially treating azotemic osteodystrophy.

    Area of Science:

    • Nephrology
    • Biochemistry
    • Nuclear Medicine

    Background:

    • Maintenance hemodialysis patients often experience progressive skeletal calcium loss.
    • Azotemic osteodystrophy is a common complication in patients with chronic kidney disease.

    Purpose of the Study:

    • To monitor skeletal calcium changes in hemodialysis patients.
    • To evaluate the efficacy of magnesium therapy, oral calcium supplements, and a vitamin D analogue in preserving or increasing bone calcium content.

    Main Methods:

    • Neutron activation analysis was employed to measure skeletal calcium levels in the hand.
    • Patients received either supplementary magnesium, oral calcium, or 1-alpha-hydroxycholecalciferol.

    Main Results:

    • Supplementary magnesium therapy reduced skeletal calcium loss in some patients.
    • Oral calcium supplements decreased skeletal calcium losses in all patients studied.
    • 1-alpha-hydroxycholecalciferol significantly increased bone calcium content in three patients.

    Conclusions:

    • Magnesium and oral calcium show potential in mitigating bone loss during hemodialysis.
    • 1-alpha-hydroxycholecalciferol may be a safe and effective treatment for azotemic osteodystrophy in hemodialysis patients.

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