Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apoptosis and carcinogenesis

S K Lyons1, A R Clarke

  • 1Department of Pathology, University of Edinburgh, UK.

British Medical Bulletin
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Increased apoptosis is common in tumors, but its exact role in cancer development is unclear. Transgenic models reveal genetic lesions that disrupt apoptosis, promoting cancer by blocking cell death or increasing mutations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Co-occurrence structure of late Ediacaran communities and influence of emerging ecosystem engineers.

Proceedings. Biological sciences·2024
Same author

Correction: Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium.

Oncogene·2024
Same author

A comprehensive phylogeny helps clarify the evolutionary history of host breadth and lure response in the Australian Dacini fruit flies (Diptera: Tephritidae).

Molecular phylogenetics and evolution·2022
Same author

Characteristics of adult- compared to childhood-onset type 1 diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2020
Same author

Short communication: Effect of a citrus extract in lactating dairy cows.

Journal of dairy science·2017
Same author

Unisexual broods and sex ratios in a polyembryonic encyrtid parasitoid (Copidosoma sp.: Hymenoptera).

Oecologia·2017
Same journal

Augmentation in Achilles tendon repair: evidence versus enthusiasm.

British medical bulletin·2026
Same journal

Regional musculoskeletal pain in workers-is the traditional medical model increasing disability?

British medical bulletin·2026
Same journal

Human health in relation to visible, functional, and accessible green space: a systematic review and narrative synthesis of the 3 + 30 + 300 guideline.

British medical bulletin·2026
Same journal

Muscle herniae in exercise-induced leg pain: diagnostic pitfalls and the 'repair paradox'.

British medical bulletin·2026
Same journal

Scaffolds and platelet concentrates in bone regenerative medicine: applications, mechanisms, and future approaches.

British medical bulletin·2026
Same journal

Back squat and deadlift fatiguing protocols elicit distinct countermovement jump profiles: phase-specific predictors and soreness responses.

British medical bulletin·2026
See all related articles

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Many tumors exhibit elevated apoptosis, indicating its significance in tumor development.
  • The precise role of apoptosis in early carcinogenesis and tumor suppression remains incompletely understood.
  • Understanding apoptosis is crucial for deciphering cancer development mechanisms.

Purpose of the Study:

  • To investigate the role of apoptosis in tumor development and carcinogenesis.
  • To identify genetic lesions affecting the apoptotic pathway and cancer predisposition.
  • To elucidate how modified apoptotic responses contribute to tumor suppression.

Main Methods:

  • Creation of transgenic model systems with modified apoptotic responses.
  • Identification of genetic lesions impacting apoptosis and malignancy.

Related Experiment Videos

  • Analysis of how these lesions affect growth control and mutation burden.

    • Main Results:

    • Genetic lesions were identified that directly block apoptosis induction.
    • Other lesions were found to indirectly promote cancer by increasing selective pressure for genetic change.
    • Deregulation of growth control and increased mutation burden were observed.

    Conclusions:

    • Normal apoptosis induction plays a pivotal role in tumor suppression.
    • Disrupting apoptosis contributes to key steps in carcinogenesis, including uncontrolled growth and increased mutation rates.
    • Transgenic models are valuable tools for understanding the genetic basis of cancer and apoptosis.